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Find a Clinic Enter your city, postcode, or click use my location to find your closest nSTRIDE clinic. Looking for a clinic nearer to you?More clinics are joining all the time. Please email any enquiries to FindAClinicnSTRIDE@zimmerbiomet.com Find a Clinic

Find a Clinic

Enter your city, postcode, or click use my location to find your closest nSTRIDE clinic.

Looking for a clinic nearer to you?
More clinics are joining all the time.
Please email any enquiries to FindAClinicnSTRIDE@zimmerbiomet.com

References

1. E Kon, L.E., P Verdonk, S Nehrer, G Filardo, Autologous Protein Solution Injections for the Treatment of Knee Osteoarthritis 3-Year Results. The American Journal of Sports Medicine, 2020. 48(11): p. 2703-2710

2. Matuska A, O’Shaughnessey K, King, W., Woodell-May J. (2013): Autologous solution protects bovine cartilage explants from IL-1. and TNF.-induced cartilage degradation. Journal of Orthopaedic Research. 31(12):1929-35.

3. Prospective Post-Market Data Collection on Patients with Knee Osteoarthritis and Treated with nSTRIDE Autologous Protein Solution, in REGP-22-00 PROGRESS III. 2020: Clinical Investigation Report.

4. J Hix, M.K., R Foreman, E Cullen, K Toler, W King, J Woodell-May, An Autologous Anti-Inflammatory Protein Solution Yielded a Favorable Safety Profile and Significant Pain Relief in an Open-Label Pilot Study of Patients with Osteoarthritis. BioResearch Open Access, 2017. 6(1): p. 151-158.

5. van der Weegen W, van Drumpt R, Toler KO, Macenski MM. (2015): Safety and outcomes following a single Autologous Protein Solution injection for knee osteoarthritis: A Pilot Study. International Cartilage Repair Society, #6471, 8-11 May, Chicago, IL.

6. O’Shaughnessey K., Matuska A., Hoeppner J., Farr J., Klaassen M., Kaeding C., Lattermann C., King W., Woodell-May J., “An Autologous Protein Solution prepared from the blood of osteoarthritic patients contains an enhanced profile of anti-inflammatory cytokines and anabolic growth factors,” Journal of Orthopaedic Research, 2014, 32(10):1349-55.

7. APS IFU (01-50-1489)

8. P Wehling, C.M., D Frisbie, et al, Autologous conditioned serum in the treatment of orthopedic diseases: the orthokine therapy. BioDrugs, 2007. 21(5): p. 323-32.

9. A Multicenter, Double-Blind, Randomized, Placebo [Saline]-Controlled Pilot Study of a Single, Intra-Articular Injection of Autologous Protein Solution in Patients with Osteoarthritis of the Knee. Clinical Investigation Report – 36 Month, APSS-33-00, Version 1.0. 14. January 2019.† † As measured by WOMAC pain scores reported by patients continuing follow-up through 3 years (n = 19). 19 out of the original cohort of 31.

10. Bertone AL, Ishihara A, Zekas LJ, et al. (2014): Evaluation of a single intra-articular injection of Autologous Protein Solution for treatment of osteoarthritis in horses. American Journal of Veterinary Medicine. 75(2):141-151.

11. APSS-33-00 Clinical Investigation Report; Zimmer Biomet: “A Multicenter, Double-Blind, Randomized, Placebo [Saline]-Controlled Pilot Study of a Single, Intra-Articular Injection of Autologous Protein Solution in Patients with Osteoarthritis of the Knee-60 month;,” Ver. 1; July 1, 2021.

12. Knee pain: MedlinePlus Medical Encyclopedia https://medlineplus.gov/ency/article/003187.htm

13. NHS UK. (12 January 2021). Knee pain. NHS UK. https://www.nhs.uk/conditions/knee-pain/

14. https://www.keele.ac.uk/media/keeleuniversity/ri/primarycare/bulletins/MusculoskeletalMatters1.pdf

15. Nordqvist C. (2014): What Is Arthritis? What Causes Arthritis? Medical News Today. MediLexicon International. n.d. Web. 7 Aug. 2014. http://www.medicalnewstoday.com/articles/7621.php

16. Osteoarthritis in General Practice: Data and Perspectives. Arthritis Research UK. 19 July 2013. n.d. Web. 8 Aug. 2015. http://www.arthritisresearchuk.org/ policy-and-public-affairs/reports- and-resources/reports.aspx

17. NHS. (2021). Osteoarthritis. NHS UK. https://www.nhs.uk/conditions/osteoarthritis/

18. Arthritis of the Knee-OrthoInfo – AAOS. American Academy of Orthopaedic Surgeons. n.d. Web. 8 Aug. 2014. http://orthoinfo.aaos.org/topic.cfm?topic=A0021

19. Goldring MB. (2000): The role of the chondrocyte in osteoarthritis. Arthritis Rheum. 43(9):1916-1926.

20. Woodell-May J, Matuska A, Oyster M, et al. (2011): Autologous protein solution inhibits MMP-13 production by IL-1beta and TNF alpha-stimulated human articular chondrocytes. Journal of Orthopaedic Research. 29 (9):1320-6

21. Research Joint Replacement / Knee Pain Knee Pain Overview. Knee Pain Overview: Knee Surgery, Partial/Total Knee Joint Replacements. Biomet, n.d. Web. 11 Aug. 2014. http://www.biomet.com/patients/knee_overview.cfm

22. Van Genechten et al. (2020): Autologous protein solution as selective treatment for advanced patellofemoral osteoarthritis in the middle-aged female patient: 54% response rate at 1year follow-up. Knee Surg Sports Traumatol Arthrosc 10-06064

23. van Drumpt AM et al. (2016): Safety and Treatment Effectiveness of a Single Autologous Protein Solution Injection in Patients with Knee Osteoarthritis. BioResearch Open Access, Volume 5.1, p. 261 – 268

24. Woodell-May J, Steckbeck K, King W. (2021): Potential Mechanism of Action of Current Point-of-Care Autologous Therapy Treatments for Osteoarthritis of the Knee—A Narrative Review. International Journal of Molecular Sciences (22) 2726

25. King W, Bendele A, Marohl T, Woodell-May J (2017): Human blood-based anti-inflammtory solution inhibits osteoarthritis progression in a meniscal-tear rat study. Journal of Orthopaedic Research 2260-2268 DOI 10.1002/jor.23528

26. Nicholas J. London, Larry E. Miller, Jon E. Block, Clinical & Economic Consequence of the treatment gap in knee osteoarthritis management, Medical Hypotheses, Volume 76, Issue 6, 2011, 887-892

27. Physical Activity for Arthritis | CDC NHS UK. (12 January 2021). Knee pain. NHS UK. https://www.nhs.uk/conditions/knee-pain/

28. Unloader Knee Brace for Osteoarthritis (verywellhealth.com) https://www.verywellhealth.com/what-is-an-unloader-knee-brace-2552051

29. Wang K, Hyun K, Felson DT, Xu L, Kim DH, Nevitt MC, Yoshimura N., Kawaguchi H, Lin J, Kang X, Zhang Y. (2018): Radiographic Knee Osteoarthritis and Knee Pain: Cross-sectional study from Five Different Racial/ Ethnic Populations. Nature Scientific Reports 8:1364

30. Kinds MB, Welsing PMJ, Vignon EP, Bijlsma JWJ, Viergever MA. (2011): A systematic review of the association between radiographic and clinical osteoarthritis of hip and knee. Osteoarthritis and Cartilage 19: 768-778.

31. Cartilage damage - NHS (www.nhs.uk)

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^Laboratory studies are not necessarily indicative of clinical outcomes.
*As measured by WOMAC pain scores reported by patients continuing follow-up through 3 years (n = 19).
19 out of the original cohort of 31.