Knee pain questions

Knee pain questions

What is nSTRIDE® APS?

nSTRIDE is a protein solution collected from your own body for the treatment of Osteoarthritis.3
Treatment with the nSTRIDE procedure is designed to provide a solution from inside you that treats OA which has been demonstrated in studies to help alleviate pain long-term4 and regain mobility and function in the arthritic knee.3


How does nSTRIDE work?

nSTRIDE will be injected directly in the knee joint. Positive outcomes are possible due to the presence of high concentrations of anti-inflammatory proteins.2

These “good” proteins may help stimulate a biologic cascade, which has been shown to block cartilage destruction in osteoarthritis.3^ The pain in the joint may be reduced, and the joint function may be improved. The treatment is designed to be a single injection therapy in the doctor’s office.

What is nSTRIDE made of?

The nSTRIDE kit processes the patient’s own blood in the clinic to concentrate white blood cells, platelets and plasma proteins into a small volume of plasma. The output is approximately 2 to 3cc of anti-inflammatory solution.

How is nSTRIDE given?

2-3cc of final output will be injected directly in the knee joint.

The nSTRIDE procedure

Your local nSTRIDE clinic takes your blood and they harvest the white blood cells from it.

Within 20 minutes blood is processed to make anti-inflammatory proteins.

Your local nSTRIDE clinic injects those proteins back into your joint.

Your local nSTRIDE clinic injects those proteins back into your joint.

What are the side effects?

You may experience side effects (e.g. bruising, local pain or swelling) associated with the blood draw, knee injection, MRI or X-ray procedures.

Will nSTRIDE cure my OA?

There is no cure for OA.21 But successful treatment with nSTRIDE may reduce or relieve your pain, which may increase your mobility and comfort.6 Your osteoarthritis may not improve or may get worse.

What are the main benefits of nSTRIDE?

nSTRIDE may significantly decrease or eliminate pain, reduce stiffness and help restore mobility and flexibility.1,6,11*

When will the treatment start to work?

Pain relief may be expected after one to two weeks.6,11*

Is nSTRIDE safe?

Yes. Studies have demonstrated the safety of nSTRIDE.6

Will I be able to be as active as usual during the course of my treatment?

It is recommended that you minimise your activity level for 14 days and not exceed pre-injection activity levels.1,6,10,11*

How long can I expect the benefits to last?

Based on preclinical and early clinical results, patients may expect to see targeted relief from knee pain for up to 5 years.11

Who can be treated with nSTRIDE?

Patients with mild to moderate knee osteoarthritis can receive the nSTRIDE treatment.

How many injections of nSTRIDE are required?

Clinical studies have demonstrated the effectiveness of one injection. These studies suggest one injection can last up to 5 years.11

Where can I have the treatment?

The injection can be given in a clinic room designated by your clinician. This is usually somewhere in a hospital or medical facility. Find your closest nSTRIDE clinic and book a consultation to see if nSTRIDE is right for you.


Can I be accompanied by my family at the clinic?

Yes. Your family can attend with you. Your clinician may ask for a limited number or that family members stay outside the room while taking blood samples or during injection for certain reasons, such as infection policies at the clinical site, but this can be discussed with your clinician.

Your knee pain

Your guide to knee pain, including what to do and when to get help.


What is nSTRIDE?

Learn about the science behind nStride and how it can get you back in touch with living the life you want to live.


Talk to a specialist

If you believe nSTRIDE is suitable for you, we can put you in touch with the right person.