What is
nSTRIDE?®

nSTRIDE® is a treatment for your knee joint designed to alleviate pain and bring balance back to your inflamed knee by introducing high levels of “good” proteins concentrated from your own blood. These good proteins can block the “bad” proteins which are responsible for the inflammatory condition in your joint. Other “good” proteins can then contribute to the health of your cartilage.5 In just one treatment, nSTRIDE® can reduce pain in the knee joint, improve joint function and may slow the destruction of cartilage.4,16

Significantly reduces pain associated with knee OA up to three years1-3*
70% improvement in knee pain following a single treatment1,2*
Significantly improves mobility in the knee joint associated with OA1,3,14*

nSTRIDE® Helps Restore the Balance

nSTRIDE® is a novel therapy (from your own body) designed to treat pain1,3 and slow the progression of cartilage degradation and destruction in the knee.4^ nSTRIDE® processes your own blood to provide a true novel output. The unique output is injected directly into the knee joint distributing beneficial and good proteins.5 In laboratory testing, these “good” proteins block and slow the degradation of cartilage treating the underlying cause of OA knee pain, unlike traditional therapies.4^

What is an Autologous Treatment?

‘Autologous’ means ‘it comes from you’. By taking a sample of your own blood, your doctor can process the blood to extract and concentrate certain molecules.5 “Good” proteins have a therapeutic effect on the OA process happening in your knee.

nSTRIDE® is the only ‘autologous anti-inflammatory’ treatment. This means nSTRIDE® works by targeting the inflammation in your knee joint and treating the ‘mechanism of wear’ by using a natural solution sourced from within you.4^,5

The nSTRIDE® Procedure

Your local nSTRIDE® clinic takes your blood and they harvest the white blood cells from it.
Within 20 minutes blood is processed to make anti-inflammatory proteins.
Your local nSTRIDE® clinic injects those proteins back into your joint.
Your pain is reduced, your mobility and your disease progression might slow down.

Science Behind nSTRIDE®

In an osteoarthritic knee, inflammatory cytokines (“bad” proteins) outnumber anti-inflammatory cytokines (“good” proteins) causing an imbalance resulting in knee pain and cartilage degeneration.11

The inflammatory proteins IL-1 and TNFa attack the cartilage11 These “bad” proteins must be stopped simultaneously to decrease pain and slow cartilage degeneration.

The nSTRIDE® treatment introduces high levels of “good” proteins (IL-1ra, sIL-1R, sTNF-RI, and sTNF-RII)10 that is designed to overwhelm and block the inflammatory cytokines (bad proteins) IL-1 and TNFa.15^ Laboratory, animal and human studies have shown that nSTRIDE® has decreased pain and

slowed cartilage degeneration, unlike traditional therapies.3^,4,14

While balance is being restored to the knee, anabolic (building) growth factors (IGF-1 and TGF-.1) are also introduced for beneficial cartilage health.10 Therefore, nSTRIDE® creates a novel therapy, which may reduce pain in the knee joint, may improve joint function and slow the destruction of cartilage.4^

This Autologous Anti-Inflammatory treatment is provided in a single session in the doctor’s office.

In an osteoarthritic knee, inflammatory cytokines (“bad” proteins) outnumber anti-inflammatory cytokines (“good” proteins) causing an imbalance resulting in knee pain and cartilage degeneration.11

The inflammatory proteins IL-1 and TNFa attack the cartilage11 These “bad” proteins must be stopped simultaneously to decrease pain and slow cartilage degeneration.

The nSTRIDE® treatment introduces high levels of “good” proteins (IL-1ra, sIL-1R, sTNF-RI, and sTNF-RII)10 that is designed to overwhelm and block the inflammatory cytokines (bad proteins) IL-1 and TNFa.15^ Laboratory, animal and human studies have shown that nSTRIDE® has decreased pain and slowed cartilage degeneration, unlike traditional therapies.3^,4,14

While balance is being restored to the knee, anabolic (building) growth factors (IGF-1 and TGF-.1) are also introduced for beneficial cartilage health.10 Therefore, nSTRIDE® creates a novel therapy, which may reduce pain in the knee joint, may improve joint function and slow the destruction of cartilage.4^

This Autologous Anti-Inflammatory treatment is provided in a single session in the doctor’s office.

See How it Worked For Me

Testimonial*

Carey, late 50s

Background:

Carey was a science teacher in Manchester. She had a major accident at work in 1999 when a heavy oak blackboard fell off the wall and pinned her to a teaching bench.
 
She fractured her spine in three places, suffered a prolapsed disc and sustained considerable nerve damage which meant she was bed-bound for three years. She had numerous operations and physio, but the medication for her back caused renal artery stenosis which caused high blood pressure. In 2006, this resulted in a stroke which went to her optic nerve and left Carey blind.
 
Lack of mobility meant she put on weight, and she developed painful OA of the knee. Carey had an arthroscopy which helped for a couple of years but then the pain returned.
 
Pain:
 
The pain was excruciating. Emotionally I became very depressed and frustrated because there were things I wanted to do but couldn’t. I couldn’t even get down the stairs in the end so I was literally trapped in my own home.
 
Within a year I went from a pain level of 0-10. It progressed quite quickly. Any movement you make uses your knees and the pain was just so debilitating. I really struggled even to great downstairs and I got to the point where I would rather have chopped my leg off than go on.
 
Treatment:
 
I walked out of the hospital myself and was out of pain within two days. The results have been amazing. My knee is back to normal.
 
It was nothing short of a miracle. They take blood from your arm, centrifuge it and then put it back into your knee. Within two days I noticed that the pain had gone and in about two and-a-half weeks I noticed I was walking down the stairs normally. Almost without thinking, I was able to bend my knees, walk the dog, go on the exercise bike and play with my grandson. Because I am now active, I have lost a lot of weight and I feel so much better in myself. It has literally given me my life back. If my knee started hurting again tomorrow I would not hesitate to go back and have another injection. The great thing is you don’t need any preparation like you would for an operation, and because there is no post surgery recuperation period afterwards there is no impact on your family and friends who would otherwise have to look after you.
 
You can also come off also powerful painkillers which really do have quite nasty side effects, particularly if they interact with other medication. Having nSTRIDE® was the best decision I have ever made and to anyone considering having the treatment I would say – “Just go for it, it is so easy, so quick, go for it.”
 

*Results are not necessarily typical, indicative, or representative of all recipient patients. Results will vary due to health, weight, activity and other variables. Not all patients are candidates for this product and/or procedure. Only a medical professional can determine the treatment appropriate for your specific condition. Appropriate post-procedure activities and pain will differ from patient to patient. Talk to your physician about whether nSTRIDE is right for you.

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Testimonial*

David, early 70s

Background:

David is a 72 year-old man who was previously very active but suffering from wear and tear OA of the knees – the pain was worse in his right knee.
 
His pain had got worse over several years, so he received nSTRIDE® on his right knee and then within a month had nSTRIDE® on his left knee too.
 
Pain:
 
I live in the present – that’s all you’ve got.
 
My wife Jackie will tell you, I never just sit round and do nothing. There’s always something to do, and if you can’t do things because you hurt too much, it is frustrating and you think ‘am I going to be just stuck in a chair?’ Because I’m a firm believer in use it or lose it. The constant pain gradually strips you of the life you once had and just grinds you down. Simple daily tasks like getting downstairs, having a bath and emptying the bins all became a painful struggle.
 
Treatment:
 
What was wonderful was we walked in at 9 o’clock and we walked out at 12 o’clock. I hadn’t had any unusual drugs stuck into me; it was a totally natural bit of my own body and I have to say I noticed the difference waking up the next day.
 
Within two days the pain had completely gone. This was just wonderful, and I had the procedure done on my left knee. Now I have two knees that don’t hurt. My blood is wonderful! I can go back to doing all the things I wanted to do before, so It has enabled me to have a new lease of life. 
When you are inside a wave and it just breaks it’s just wow. When one wave catches up to another it’s like driving a sports car and to be able to go back and get in a wave and go and I don’t have to give that up… And waves are free, so in that way it has been life changing to me.
 

*Results are not necessarily typical, indicative, or representative of all recipient patients. Results will vary due to health, weight, activity and other variables. Not all patients are candidates for this product and/or procedure. Only a medical professional can determine the treatment appropriate for your specific condition. Appropriate post-procedure activities and pain will differ from patient to patient. Talk to your physician about whether nSTRIDE is right for you.

Read More
*Results are not necessarily typical, indicative, or representative of all recipient patients. Results will vary due to health, weight, activity and other variables. Not all patients are candidates for this product and/or procedure. Only a medical professional can determine the treatment appropriate for your specific condition. Not for distribution in France.

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